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is a key determinant of paclitaxel sensitivity in MCF 7 breast cancer cells. My research focuses on CAV1 and its possible role in promoting cell death in response to paclitaxel by inhibiting the function of a pro survival protein called survivin. The upregulation of survivin is associated with cancer and we show that while overexpression of CAV1 down regulates survivin dr martens damen, tridentate and tetradentate ligands have been synthesized in this work with the aims of: (i) developing efficient emitters for potential incorporation into light emitting electrochemical cells (LECs) and (ii) contributing novel design structures to the field of coordination photochemistry. Chapter 2 focuses on Ir(III) complexes of the type
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